Abstract

FORMULATION & EVALUATION OF ACYCLOVIR MICROBEADS

Syed Gouse Firoz*, Jyoti Sahu and Fatima Shireen

Abstract

The present study is concerned with the formulation and evaluation ofacyclovir microbeads in the presence of polymer. Acyclovir drug is anantiviral drug which is preferentially taken up by the virus infectedcells and thus it inhibits DNA synthesis and viral replication but only20 percent of oral dose is absorbed as it is having less plasma proteinbounding and having t ½ life is 2-3 hours. Microbeads are prepared toovercome its less oral absorbent to obtain prolonged controlled drugdelivery, to improve bioavailability or stability of drug. This articlecontains different concentration of polymer (Chitosan and sodiumalginate) and excipients to prepare Acyclovir microbeads which increase bioavailability byincreasing t ½ life elimination i.e maximum up to 12 hours.

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