Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL EVALUATION OF PUNARNAVADI YAVAKUTA IN THE MANAGEMENT OF HYPOTHYROIDISM

Karishma Singh*, Harisha C. R., Shukla V. J. and Anup B. Thakar

Abstract

Thyroid diseases are common worldwide. In India too, there is a significant burden of thyroid disease. Hypothyroidism, specifically, is the most widespread thyroid disorder in India, affecting one in ten adults. Researchers have been trying since long to unfold the pathogenesis of Hypothyroidism. The concepts of Agnimandya and Ama in Ayurveda have much in common with Hypothyroidism. The clinical presentation of the disease is very much similar to the Ama lakshanas. The Sole causative factor for Ama formation is Agnimandya. The trial drug Punarnavadi Kashaya, cited in Chakradutta for the management of Shotha, contains Deepana, Anulomana, Shothahara and Vatakapha shamaka drugs, targeting at the core cause of disease. Pharmacognostical & Analytical study of Punarnavadi Yavakuta has been carried out for evaluation of its efficacy in Hypothyroidism. On pharmacognostical study, Acicular crystals of Punarnava, Cork cells of Shunthi, Fibres through medullary rays of Devadaru, Sceleriform vessels of Shunthi, Lignified pitted vessels of Punarnava, Tannin content of Devdaru, Oil globules and crystal fibres of Devdaru, Phloem fibres of Devdaru, Pitted vessels of Punarnava, Lignified and crystal fibres of Devdaru were found. Analytical study showed 9 spots at 254 nm and 8 spots at 366 nm.

Keywords: Agnimandya, Ama, Hypothyroidism, Punarnavadi Kashaya.