Abstract

A CASE REPORT ON SERRATIOPEPTIDASE INDUCED INTERNAL BLEEDING IN A PATIENT WITH BEHÇET'S ILLNESS

Dr. P. Venkata Ramana*, Thumpera Aravind, S. Ayesha, A. Jayasree  and C. T. Anjana Devi

Abstract

Serratiopeptidase is a product of enterobacterium Serratia species which is acting as a proteolytic enzyme. Enterobacterium Serratia species is isolated from the intestine of silkworm. Serratiopeptidase is called by several names like serralysin, serratia peptidase, serratiapeptase, Serratiopeptidase, or serrapeptidase. A 28-year old Syrian woman with Behçet’s Disease was admitted to emergency department with a large number of ecchymotic foci on her body surface. She had a history of Behçet’s Disease for 4 years. The patient explained that she had experienced venous thrombosis one year ago, and she also had this disorder edema develoloped in her legs right after having the venous thrombosis. The patient also said that she was recommended to use Serratiopeptidase continuously to prevent the development of some kind of thrombosis as well as to prevent from having the edema in her legs. Behcet's disease is a multi systemic chronic inflammatory disease. It was first described as a triple complex of recurrent oral ulcers, genital ulcers and uveitis. Vascular thrombosis is a serious issue and it might accompany to the course of Behçet's disease. In controlling vascular thrombosis anticoagulants, antiplatelet or antifibrinolytic agents were not recommended because of the high bleeding risk. While taking these drugs or proteolytic herbal drugs to prevent thrombosis, bleeding risk should be taken into consideration.

Keywords: Behcet's disease, Serratiopeptidase, diffuse ecchymotic hemorrhage.