Abstract

FORMULATION AND IN VITRO EVALUATION OF FLOATING MICROSPHERES OF ATOMOXETINE HCL

S.Swathi*, Potlapally Laxmi, Azeez Mohammad, G.Shirisha

Abstract

In Research work an attempt was made to prolong the gastric residence time of Atomoxetine Hcl and by fabricating it into floating sustained release microspheres. Atomoxetine Hcl is a non- stimulant drug used for the treatment of ADHD. Atomoxetine has good oral absorption profile, an oral bioavailability of 63%and a plasma elimination half-life of 5 hours. The floating microspheres were prepared by using bio compatible polymers like ethyl cellulose along with the drug in different proportions by Non-aqueous solvent evaporation method. The microspheres were characterized for micromeritic properties, percentage entrapment efficiency, percentage yield, Mean particle size, In-vitro buoyancy, In-vitro drug release studies. It was observed the increase in concentration of ethyl cellulose increases the entrapment efficiency and particle size of the microspheres. The data obtained in this study thus suggests that a micro particulate floating dosage form of Atomoxetine Hcl can be successfully designed to give prolonged release of drug and hence improved bioavailability.

Keywords: Atomoxetine Hcl, floating microspheres, Ethyl cellulose.