Abstract

CASE REPORT – CARBAMAZEPINE INDUCED TOXIC EPIDERMAL NECROLYSIS

Dr. Shweta Sharma*, Dr. Juhi Singla, Dr. Naveen Kumar, Dr. Vineeta Mittal

Abstract

Toxic epidermal necrolysis (TEN), also known as Lyell’s syndrome, is a widespread life-threatening mucocutaneous disease where there is extensive detachment of the skin and mucous membrane. Many factors involved in the etiology of TEN including adverse drug reactions. Here we are reporting a case of toxic epidermal necrolysis in a 50 year old female patient after receiving Carbamazepine. On the 24th day of Carbamazepine, patient developed burning sensation in the eyes and oral ulcers followed by blisters which first appeared on the trunk, chest and arms. The erythematous rash was covering almost all over the body with epidermal detachment of 70% body surface area. There was loss of eye lashes, congestion of conjunctiva with mucopurulent discharge and exposure keratitis. The clinical impression was TEN induced by Carbamazepine. Carbamazepine was stopped immediately. She was treated with high dose of intravenous corticosteroids, systemic and topical antibiotics. After one month, the progression of the skin lesions halted and she was discharged.

Keywords: Carbamazepine, Stevens-Johnson syndrome, Toxic epidermal necrolysis.