Abstract

REVIEW SYNTHESIS OF VARIOUS BENZIMIDAZOLE DERIVATIVES AND ITS POTENTIAL BIOLOGICAL ACTIVITY

Prof. Dr. Mathew George*, Prof. Dr. Lincy Joseph and Umesh Kumar

Abstract

Benzimidazole is an important pharmacophore which was included in several biologically active compounds resulted in the development of several classes of drugs.[1] Compounds having benzimidazole as a structural motif have been widely used in medicinal chemistry and drug development, and researchers are actively seeking new uses and applications of this heterocycle.[2] In 1990 various benzimidazole derivatives were synthesized with substitution of fluorine, propylene, tetrahydroquinoline and cyclized compound which resulted in compounds with increased stability, bioavailability and significant biological activity.[3] This review summarizes some potential biological activities shown by benzimidazole derivatives in recent years.

Keywords: Benzimidazole, Heterocycle, Biological Activity.