Abstract

ACETOPHENONE BASED MANNICH BASES: SYNTHESIS, CHARACTERIZATION AND THEIR ANTI-BACTERIAL ACTIVITY

K. Chithra, K. Jayanthi and D. Satheesh*

Abstract

Five new Mannich bases, 3-[N’-(2,4-Dinitro-phenyl)-hydrazino]-3-(4- methoxy-phenyl)-1-phenyl-propane-1-one (4a), 3-[N’-(2,4-Dinitrophenyl)- hydrazino]-1,5-diphenyl-pent-4-en-1-one (4b), 3-[N’-(2,4- Dinitro-phenyl)-hydrazino]-1,5-diphenyl-pent-4-en-1-one (4c), 3-[N’- (2,4-Dinitro-phenyl)-hydrazino]-3-(4-nitro-phenyl)-1-phenyl-propane- 1-one (4d), 3-[N’-(2,4-Dinitro-phenyl)-hydrazino]-3-(2-hydroxyphenyl)- 1-phenyl-1-propane-1-one (4e) have been synthesized and characterized by chemical and spectral analyses such as UV-Visible, FT-IR, 1H NMR and 13C NMR. All the synthesized compounds 4a-4e was screened for their antibacterial activities against the Gram-positive bacteria (Staphylococcus aureus and Bacillus species), Gram-negative bacteria (Escherichia coli and Salmonella typhi). Compounds 4c and 4d of the series showed good activities against Bacillus species.

Keywords: Mannich base, Acetophenone, Benzaldehyde derivatives, Cinnamaldehyde.