Abstract

SYNTHESIS AND EVALUATION OF NEW BIS-ISATIN DERIVATIVES FOR CYTOTOXIC ACTIVITY

K.Karthik, K.Blessi Priyanka, C.Manasa, G.Sammaiah*

Abstract

The objective of the present work is to synthesize a new series of (N'1, N’2-bis [2-oxoindolin-3-ylidene] phthalohydrazides) and evaluated for cytotoxic activity. All the compounds were screened by MTT assay method. The results of this study revealed that all synthesized compounds significantly cytotoxic in a concentration dependent manner. The IC50 values of all test compounds were found to be between 21.20 and 37.48 mM. All the synthesized compounds have shown moderate antioxidant activity.

Keywords: Bis-isatin, cytotoxic, MTTassay, (N'1,N’2-bis[2-oxoindolin -3- ylidene] phthalohydrazides).