Abstract

ULTRA DEFORMABLE ELASTIC VESICLES TRANSFEROSOMES FOR ENHANCED SKIN DELIVERY- AN UPDATE

* Pushpa Anand, A. Samnani, M. Bhoumick, B.K. Dubey

TIT College of pharmacy,Bhopal M.P. INDIA

Abstract

The skin acts as a major target as well as a principle barrier for topical/transdermal drug delivery. The stratum corneum plays a crucial role in barrier function for transdermal drug delivery. Despite major research and development efforts in transdermal systems and the advantages of these routes, low stratum corneum permeability limits the usefulness of topical drug delivery. To overcome this, methods have been assessed to increase permeation. Transferosomes is a supramolecular entity that can pass through a permeability barrier and there by transport material from the application to the destination site. These are more elastic than standard liposomes. Transferosomes have been widely used as a novel carrier for effective transdermal drug delivery. Transferosomes enhances the penetration of most of the low as well as high molecular weight drugs,while in case of lipophilic drugs the entrapment efficiency can reach upto 90%. it is now widely used as a novel carrier for both systemic as well as topical delivery of drugs. Transferosomes have easily deformable properties so that it can easily squezz out from the stratum corneum, and the mechanism for penetration is the generation of “osmotic gradient” due to evaporation of water while applying the lipid suspension (transferosomes) on the skin surface.Flexibility of transferosomes membrane is achieved by mixing suitable surface active components in the proper ratios. Transferosome penetrate the stratum corneum by either intracellular route or the transcellular route. With the excellent distribution property of transferosomes, it has been widely used as a carrier for various proteins , steroids, NSAIDS,and anti cancer agents etc.

Keywords: Transferosomes, Stratum corneum, transdermal drug delivery.