Abstract

FORMULATION AND EVALUATION OF CONTROLLED MICROPOROUS OSMOTIC TABLETS OF RIVASTIGMINE HYDROGEN TARTRATE

Sridhar Rao. K, Uday Kumar.G*, Harisha Kumari. M

Abstract

Extended release formulation of Rivastigmine hydrogen tartrate based on osmotic technology was prepared and evaluated. The tablets were prepared by wet granulation method. Rivastigmine hydrogen tartrate is an ideal candidate for a zero-order drug delivery system because it is freely soluble in water and has short biological half life (6hrs). Sodium chloride and mannitol were used as osmotic agents. Cellulose acetate and polyvinyl pyrrolydone were used as semi permeable membrane and pore forming agent respectively. The effect of different formulation variables, namely, concentration of osmogen in the core tablets and level of pore former in the membrane, were studied. Rivastigmine hydrogen tartrate release from the osmotic tablet was directly proportional to the level of pore former in the membrane. Drug release from the developed formulations was independent of pH and agitation intensity but dependent on osmotic pressure of release media. FTIR results indicated that there was no incompatibility between drug and excipients. The developed formulation could be used for prolong delivery for about 24 hrs of Rivastigmine hydrogen tartrate.

Keywords: Antifungal, Antibacterial, Traditional healers, Wayanad, Ethnomedicines.