Abstract

ANTIUROLITHIATIC ACTIVITY OF Scoparia dulcis IN ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE ALBINO WISTAR RATS

*Shamina .S, Jishamol. G

Abstract

The use of herbal medicines (medicinal plants or phytotherapy) has recently gained popularity in world wide. The research is lead to the new drug discovery or advances the use of indigenous herbal medicines for Urolithiasis. This revival of interest in plant derived drugs is mainly due to the current widespread belief green medicine is safe and more dependable than the costly synthetic drugs many of which have adverse side effects. The study lights up on the effect of Scoparia dulcis plant extract in ethanol. The plant extract is acting on the urolithiatic albino wistar rats induced by ethylene glycol. Urolithiasis was induced in rats by administrating 0.75 % of ethylene glycol orally for 30 days and analysed by the serum marker enzymes as ACP, ALP, AST, ALT, Creatinine and Uric acid. The toxic rats were treated with the ethanolic leaf extract of Scoparia dulcis was administered in 250 mg/kg body weight of rats orally for 30 days . The variations in the haematological profile of the urolithiasis results in the elevated levels of serum marker enzymes and increased level of Creatinine and Uric acid. This study summarized that the treatment with Scoparia dulcis is capable of counteracting the urolithiasis and it can be developed into antiurolithiatic drug.

Keywords: Urolithiasis, Scoparia dulcis, Ethylene glycol.