Abstract

ANTIMICROBIAL ACTIVITY STUDIES, PREPARATION AND CHARACTERIZATION OF NEW AZO COMPLEXES DRIVEN FROM N-(4-HYDROXYPHENYL) ACETAMIDE

Tarek A. Fahad*, Rawaa H. Yaqoob and Asaad A. Ali

Abstract

Coupling reaction of N-(4-hydroxyphenyl)acetamide with some sulfa drugs (sulfa pyrdine, Lp and sulfamethazin, Lm) gave the new bidentate azo ligand. The prepared ligands were identified by Micro elemental Analysis, 1H NMR, 13CNMR,FT-IR and UV-Vis spectroscopic techniques. Treatment of the prepared ligands with the following metal ions (Co (II), Ni(II) and Cu(II) in aqueous ethanol with a 1:2 M:L ratio and at optimum pH, yielded a series of neutral complexes of the general formula [M(L)2]. The prepared complexes were characterized using flame atomic absorption, (C.H.N) Analysis, FT-IR and UV-Vis spectroscopic methods as well as magnetic susceptibility and conductivity measurements. The isolated complexes Ni(II), Cu(II) and Co(II) of azo ligands are found to have tetrahedral structure. The biological activity of the synthesized ligands and their metal complexes also are screened K.pneumoniae, Proteus spp. and Ps.aeruginos mortality were studied.

Keywords: Azo-dyes, N-(4-hydroxyphenyl)acetamide, sulfapyridine and sulfamethazin magnetic susceptibility and conductivity measurements.