Abstract

COMPREHENSIVE INTERPRETATION OF NANOSTRUCTURED LIPID CARRIERS (NLC): A PROMISING NEW GENERATION LIPID CARRIER FOR THE DELIVERY OF CANCER CHEMOTHERAPEUTICS

Parikshit Banerjee, Arpan Mahanty, Rakotomalala Manda Heriniaina, Tiantian Li, Geng Tengjiao, Biplab Mallick and Bo Wang*

Abstract

In the last couple of years, Nano-carries have attracted large amount of consideration in drug delivery specifically for cancer chemotherapy. There are shortcomings which greatly hindered anti-cancer drug delivery such as poor-aqueous solubility, toxicity towards normal tissues, limited targeting ability, inefficient large-scale production output, rapid degradation and quick release from the formulations. The amount of studies analyzing formulations based on nanostructured lipid carriers (NLCs) has been significantly increased. This increase in NLC investigation is possibly due to its ability to overcome the physiological obstacles and enhanced understanding of mechanism of action NLCs in vitro and in vivo via different route of administration in recent years. Toxicity related concerns like- presence of organic residues and polymers are tactically bypassed by using nanostructured lipid carriers. In this review we have discussed the types, preparation procedure and physicochemical characterization technique of NLCs. In addition, the roles NLCs can play in cancer chemotherapy have also been discussed. It is expected that in foreseeable future NLCs will /stand out as a carrier with the ability to target cancers more efficiently and will present better clinical outputs.

Keywords: Nanostructured lipid carriers, cancer chemotherapy, physiological obstacles, stability, clinical outputs.