Abstract

OPTIMIZATION OF PIROXICAM MONOETHANOLAMINE LOADED GOLD NANOPARTICLES USING 23 FULL FACTORIAL DESIGN APPROACH.

Jessy Shaji* and Seema Darade

Abstract

The objective of the present study was to investigate the combined effect of three independent variables in the fabrication of Piroxicam monoethanolamine (PRX-MEA) loaded gold nanoparticles (PMAuNPs) using a 23 full factorial design. PM-AuNPs were prepared by green chemistry approach using methanolic green tea (Camellia. sinesis) extract with factors viz. gold salt concentration X1 (1.57 to 3.93 mg), PRX-MEA concentration X2 (2.86 to 8.12 mg) and reaction time X3 (60 to 180 min.) and were evaluated for their particle Size Y1 (nm) and % loading efficiency Y2 (% LE). The mean particle size of PM-AuNPs batches ranged between 43 to 158.3 nm. Preliminary trials of PM-AuNPs revealed that on increasing the gold salt concentration the particle size was also increased. The % LE was found to be between 81.94 % to 97.78%. Process variables such as gold salt and PRX-MEA concentration had positive impact on percent drug loading efficiency. The effects of all the tested independent variables were significant (P-values

Keywords: 23 full factorial design, loading efficiency (%LE), Gold nanoparticles, Optimization, Piroxicam Monoethanolamine (PRX-MEA).