Abstract

SYNTHESIS AND CHARACTERIZATION OF NOVEL SPIROAZETIDIN-2-ONES TETHERED WITH FURANS AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS

Rajala Srikala* and Medepalli Narayana Babu

Abstract

Present investigation describes about the synthesis of some novel spiroazetidinones tethered with furans. These compounds were designed, based on the structure of β-lactam, which shows antimicrobial activity. Some new 1-(substituted phenyl)-3-chloro-5,9- bis(furan-2-ylmethylidene)-1-azaspiro[3.5]nonan-2-ones (3a - 3h) were synthesized by Staudinger’s ketene–imine reaction. The structures of the newly synthesized compounds were confirmed on the basis of physical, IR, H1 NMR, mass and elemental analysis data. All the synthesized compounds were screened for antibacterial, antifungal and invitro anti-inflammatory activities and the results of some of the derivatives exhibited promising activities. The zone of inhibition values of the compound 3h showed significant antibacterial activity, compounds 3f and 3g showed highest antifungal activity and remaining compounds had shown good antimicrobial activity. Highest invitro anti-inflammatory activity was observed with compounds 3c derivative possessing electron withdrawing substituents on phenyl ring.

Keywords: Spiro, azetidinones, furan, antibacterial activity, antifungal activity, invitro anti-inflammatory activity.