Abstract

ANALGESIC ACTIVITY OF THE ETHANOLIC EXTRACT OF FLOWER PARTS OF CELOSIA ARGENTEA LINN

Dr. A. Thanga Thirupathi*, Amatul Kabeer, P. Meenakshi, G. Navya, K. Ashwini, B. Manisha and Dr. KNV. Rao.

Abstract

Celosia argentea has been widely used for its reported biological activity in indigenous system of medicines. The present investigation was carried out to found the analgesic effect of ethanolic extract of flowers of Celosia argentea in experimental animal model of pain. The analgesic activity was evaluated by acetic acid induced writhing method and by tail flick latency method in albino mice respectively. The percentage protection against writhing method showed by ethanolic extract of Celosia argentea in doses of 200 & 400mg/kg, p.o. was 24.12 & 29.60 respectively. In the tail flick model, the ethanolic extract of Celosia argentea in the above doses increased the pain threshold significantly and showed the basal reaction time of 10 & 14.25 sec respectively at third hour. After the administration of the ethanolic extract of Celosia argentea in different doses such as 200 & 400mg/kg exhibited dose dependent and significant analgesic activity in both models of pain.

Keywords: Analgesic, Celosia argentea, acetic acid induced writhing and tail flick methods.