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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

EVALUATION OF CYTOTOXIC ACTIVITY OF ANDROGRAPHIS ECHIOIDES NEES.

*Priyanka Martiwar

Abstract

The present study evaluated the preliminary phytochemical and anticancer activity of the successive extracts (with the help of ethanol and ethyl acetate of the leaves of Andrographis Echioides by brine shrimp lethality bioassay, allium cepa root tip meristem model and 3- (4, 5-dimethylthiazol-2,5-diphenyltetrazolium bromide assay. the activity was compared with Cyclophosphamide as standard. The results revealed the presence of flavonoids in leaf. The anticancer activity was showed by brine shrimp lethality bioassay, allium cepa root tip meristem model and 3-(4, 5-dimethylthiazol-2,5- diphenyltetrazolium bromide assay.

Keywords: MTT assay (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, Brine shrimp lethality bioassay (BSLB), cytotoxic activity, Flavonoids, Andrographis echioides.

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