Abstract

COMPARATIVE STUDY OF HYPOLIPIDEMIC EFFECTS OF ATORVASTATIN WITH EMBLICA OFFICINALIS (AMLA) IN PATIENTS OF TYPE II HYPERLIPIDEMIA

Abstract

Aims and objectives: The present study was undertaken for an evaluation of the effect of E. Officinalis powder on the serum lipids level & comparing standard hypolipidemic drug Atorvastatin in the patients of hyperlipidemia type II at NIMS Medical College & Hospital, Jaipur. Methods: A prospective randomized open label study was done in medicine O.P.D. NIMS Hospital Jaipur from November 2011 to April 2013 after taking ethical clearance and written informed consent. Out of 93 patients, 45 patients (Group-A) were given two tablet of Amla (500 mg) daily, while the other 48 patients (Group-B) received one tablet of Atorvastatin (10 mg) daily for 16 weeks.All routine biochemical investigations including lipid profile were performed before starting the intervention as well as after completion of each treatment round i.e at the end of 4 weeks, 8 weeks, 12 weeks & 16 weeks. Results: Amla showed significant increase in HDL and decrease in triglyceride level (P < 0.05 ) at the end of 16 wks while atorvastatin has shown better effect on TC, LDL and VLDL (P < 0.05). There was no adverse drug event in either group. Conclusion: In our study on amla when compared with atorvastatin, amla has been shown better effect on TG and HDL while atorvastatin has shown better effect on TC, LDL and VLDL.

Keywords: Hyperlipidemia, Atorvastatin, Amla(Emblica officinalis).