Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF ACECLOFENAC BY USING SYNTHETIC AND NATURAL SUPERDISINTEGRANTS

Harshal K. Patil*, Ghanshyam M. Patil, Vipul H. Jain and Sunil P. Pawar

Abstract

The present investigation deals with development of fast dissolving tablets of aceclofenac to produce the intended benefits. Fast dissolving tablets of aceclofenac were prepared using superdisintegrant croscarmellose sodium and Isabgol using the direct compression method. The tablets prepared were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in vitro disintegration time and in vitro dissolution time. The tablets disintegrated within 30 to 60 seconds. Almost 90% of drug was released from all formulations within 15 min. The formulation containing 9% of croscarmellose sodium was found to give the best results. Apart from fulfilling all official and other specifications, the tablets exhibited higher rate of release.

Keywords: Direct compression, Aceclofenac, Crosscarmellose, Isabgol, Mouth Dissolving Tablet.