Abstract

ACUTE AND 28 DAYS REPEATED ORAL TOXICITY STUDY OF THE SIDDHA DRUG VEERA AYA CHENDHURAM (VAC)

J. Sridevi* and P. Shanmuga Priya

Abstract

According to the text kannusamiyam parambarai vaithiyam, the drug Veera aya chendhuram(VAC) is used in the treatment of Anemia. Anemia is a global health problem affecting both developing and developed countries with major health consequences for human health as well as social and economic development. It is generally attributed that 50% of anemia is due to iron defeciency. Hence it is an need for an hour to evaluate safety and efficacy of the drug VAC which is indicated for anemia. Acute and 28 days repeated oral toxicity study was performed in wistar albino rats according to OECD guidelines. Acute toxicity single dose of 5mg, 50mg, 300mg and 2000mg was administered to rats and monitored for 14 days. 28 days repeated oral toxicity was carried out in two group of 10 animals (5 male and 5 female). VAC was administred in the dose of 4.68mg, 23.4mg, 46. 8mg to the rats for the period of 28 days. Detailed hematological, biochemical, histopathological evaluation of different organs were performed in all animals. The acute toxicity study results concludes that the LD 50 cut off value of VAC may be above 2000 mg/kg body weight. The histopathological report shows that the drug is considered safe in low and mid doses.

Keywords: Veera aya chendhuram, Anemia, Siddha drug, toxicity study.