Abstract

ANTI-HYPERGLYCEMIC ACTIVITY OF IPOMOEA BATATAS LINN. (LAM) ROOTS EXTRACT

R.A. Ahirrao* and N. D. Patil

Abstract

Objective: To evaluate the anti-hyperglycemic activity of methanolic extract of Ipomoea batatas roots. Materials and methods: The methanolic extract of roots of Ipomoea batatas was tested for its hypoglycemic activity in normal glucose loaded and alloxan-induced hyperglycemic Wistar rats. Blood glucose levels were evaluated at intervals of 30and 90 minutes in normal glucose loaded animals, at intervals of 0, 1 and 3h in acute study and at days 1, 3, 7 and 10 during sub acute treatment after exact administration at an oral dose of 250 mg/kg. Result and discussion: During both acute and sub-acute test, the methanol extract showed statistically significant and considerable antihyperglycemic activity and enhanced glucose tolerance in normal glucose loaded rats. Conclusion: Ipomoea batatas roots possessed statistically significant antihyperglycemic potential in alloxan induced diabetic rats and enhanced glucose tolerance in glucose loaded normal rats

Keywords: Ipomoea batatas, Antihyperglycemic activity and hypoglycemic.