Abstract

ASPERGILLUS NIGER MEDIATED SYNTHESIS OF ZNO NANOPARTICLES AND THEIR ANTIMICROBIAL AND IN VITRO ANTICANCEROUS ACTIVITY

S.Justin Packia Jacob*, R.Bharathkumar and Ashwathram.G

Abstract

Nanoparticle metal oxides represent a new class of important materials that are increasingly used in research and health-related applications. Highly ionic metal oxides are interesting not only for their wide variety of physical and chemical properties but also for their antibacterial activity. The present study describes the synthesis, characterization, antimicrobial and anticancerous screening of Zinc Oxide (ZnO) nanoparticles. The ZnO nanoparticles were prepared using the fungal filtrate and characterized using UV–visible spectroscopy, FTIR (Fourier-transform IR) spectroscopy, EDX and SEM (scanning electron microscopy) analysis. Agar-well diffusion method was used to evaluate the antimicrobial activity. The sizes of the spherical ZnO nanoparticles were found to be in the range of 39.4-114.6 nm. The results revealed that ZnO nanoparticle is an effective broad spectrum antimicrobial agent and also it exhibit significant cytotoxic effect on HEp-2 cells.

Keywords: Fungal, antimicrobial, anticancerous, ZnO Nanoparticles