Abstract

IS THERE A LINK BETWEEN DEPRESSION AND TYPE 2 DIABETES MELLITUS? A REVIEW OF SHARED MECHANISMS AND COMMON THERAPEUTIC MODALITIES

Karun Kumar* and Dr. Vikas Seth

Abstract

Type 2 diabetes mellitus (T2DM) and depression are expected to be amongst the top five causes of disease burden by the year 2030. The relationship between endocrine disturbances and psychiatric conditions has intrigued many for decades. Current researches suggest a bidirectional relationship between T2DM and depression, and, the two disorders may share similar pathophysiological mechanisms. There have been studies suggesting causal pathways between T2DM and depression. Depression was associated with a 60% increase of T2DM while T2DM was associated with 15% risk of depression. Few studies have evaluated the impact of specific antidepressant therapies on glycemic control in people with diabetes. Also, it has been reported that integrated management of T2DM and depression improves medication adherence. However, no specific guidelines have been established regarding treatment of patients with comorbid T2DM and depression. The present article is an endeavor to investigate the underlying mechanisms and treatment modalities for people suffering with comorbid T2DM and depression; thereby bringing to light hitherto unexplored arenas in this field.

Keywords: Type 2 Diabetes Mellitus, Depression, Glycemic control, antidepressants, insulin resistance.