Abstract

FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF RISPERIDONE

G. Sandhyarani*, L. Sowmya and K. Venumadhev

Abstract

Orodispersible dosage forms are used for accurate dosing, enhanced bioavailability, rapid action, patient compliance, easy of administration, enhanced palatability. Risperidone drug taste was masked with Amberlite IRP 64 (1:3) effectively. Formulations F1,F2,F3,F4,F5,F6 and F7 are formulated with different concentrations of superdisintegrents by direct compression technique. Formulation F5 with crosscaramellose and crospovidone with 2mg, 2mg respectively showed better Water absorption ratio 76.73±2.88%, wetting time 26.66±2.08 sec and disintegration time 25±1.0 sec. By considering disintegration time and dissolution time (102.85±0.23 min.) and other evaluation parameters F5 considered as optimized formula for comparision study with marketed Respiridone conventional tablet 38.02% drug released.

Keywords: Orodispersible dosage superdisintegrents crosscaramellose and crospovidone released.