Abstract

Î’ETA-CYCLODEXTRIN COMPLEX, SOLID DISPERSION AND SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS): AN APPROACH TO ENHANCE THE SOLUBILITY OF POORLY SOLUBLE DRUG

Shalini Thakur* and Kumar Hari S.L.

Abstract

The present focuses on enhancement the solubility of poorly soluble drug (BCS 11 drug) of β-cyclodextirn, solid dispersion and self emulsifying drug delivery system. The ability of β-cyclodextrin , solid dispersion and SEEDS to improve oral bioavailability of poorly water soluble drug. Β-cyclodextrin is cyclic oligosaccharides with a hydrophobic cavity and hydrophilic surface. The basic physiochemical characteristics of β-CD had been discovered, including their ability to solubilize and stabilize drugs. Cyclodextrin also effects on drug solubility and bioavailability and drug release from formulation. Cyclodextrin application in the design of various novel drug delivery systems (Liposome, Microsphere etc). Solid dispersion composed of two components the drug and polymer matrix. Solid dispersion have been improving the dissolution rate and hence the bioavailability of drugs. Numerous method are existing to prepare the solid dispersion such as melting method, solvent evaporation method etc. SEDDS are isotropic mixture of oil, surfactant, co-surfactant and co-solvent. The ability of these systems to form fine o/w emulsion & microemulsion upon mild agitation following dilution by an aqueous phase through the gastrointestinal tract for lipophilic drug which display dissolution rate limited absorption. The development of β-cyclodextrin, solid dispersion & SEDDS has been suggested in relief.

Keywords: Poorly soluble drug, ?-cyclodextrin, Solid dispersion & Self emulsifying drug delivery system, Techniques, Lipid based formulation, Bioavailability, Dissolution.