Abstract

A SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF HEALTH BENEFITS OF THE SUBSTITUTED FISETIN

Yogesh Sahebrao Waghmare*, Rajalakshmi Bothiraja and Sonali Mahaparale

Abstract

The fisetin is great for reducing inflammation and all things related to the brain function. The chemically fisetin (7, 3’, 4’-flavon-3-ol), is a plant polyphenol from the flavonoid group. Fisetin is a type of plant pigment that gives colour to many fruits and vegetables (Example Apples, Cucumber, Onions and Strawberries). It can be found in many plants, colouring agents and flavouring agents. The effect on the antimetastatic potential of cervical cancer cells remains unclear the flavonoid which is part of our daily nutrition in relatively low amounts less than 1 mg per day. In the present study it is investigate the preferential binding mode and encapsulation of the flavonoid fisetin in the nanopore of β-cyclodextrin at the molecular level using various theoretical approaches. The fisetin is protects against brain generation like antioxidant and mitochondrial activity. This was probably due to either damages caused to yeast cell envelope or the dragged out of cell. Fisetin finding identify in vivo chemo preventive efficacy of fisetin and suggest that fisetin could be used as a novel, effective and safe intravesical agent for bladder cancer. The natural product of fisetin can facilitate long-term memory and therefore it may be useful for treating patients with memory disorder. The fisetin Nano-emulsion injected intravenously (12 mg/kg IV) showing no significant difference in the systemic exposure compared to free fisetin.

Keywords: Fisetin, Encapsulation, anti-tumour activity, flavonoid, medicinal properties, proteins.