Abstract

STUDIES ON THE EFFECTS OF RED MACROALGAE EXTRACT ON ABELMOSCHUS ESCULENTUS - A NOVEL STRATEGY TO EXPRESS THERAPEUTIC COMPOUNDS

C. Elizabeth Rani Juneius*, V. Baby Rani, M. Vinoth, M. Sundari, Dr. R. Eswaralakshmi and Dr. S. Elumalai

Abstract

The present work was undertaken using a seaweed liquid fertilizer extracted from the red algae Coralline mediterranea. The study plant chosen was Abelmoschus esculentus because we had already used the same plant to study the effects of Kappaphycus alverazii and we have found out amazing results. Seaweed liquid fertilizer extracted from the red algae Coralline mediterranea were having many biologically active compounds like glycosides, flavonoids, anthraquinone, resin and tannins. Antimicrobial activity of ethanolic root extract of the study plant was carried out which showed moderate sensitivity against E.coli but the control plant root extract was resistant to E. coli. GCMS result of ethanol extract of control plant had some exclusive compounds. They were phenol -2-(1-phenyl ethyl), 1,2- Benzene dicarboxylic acid, bis(2-methyl propyl)ester, hexadeconic acid methyl ester, methyl octadec – 9-enoate, stearic acid methyl ester, linear isopropyl phenol dimer, 9-ocatadienolic acid, methyl ester and diisooctyl phthalate. Untreated but the plants closer to the vicinity of the treated plants had some exclusive compounds. They were 1,3,4-oxadiazol-2-amine,5-phenyl, 1,6- dimethyl(1,2,4)triazole(3,4-c) (1,24) triazin-5(1H)-one, acetone,N2-(4-hydroxy-6-methyl pyrimidine-2-yl)hydrazine, 2-methoxyethyl semithiocarbaxide and 2H-Imidazole-2- thione,1,3-dihydr. All these compounds were absent in the treated plant root extract but it had phenol, 2-amino-4-(1H-1,2,3,4 tetrazole) 1-yl and Hydrazine -2-imidazole as an exclusive compounds. Though the peak compounds for both treated plants and the plants in the adjacent lane of treated were same but amount of 13-Heptadecyn-1-ol was 88.15% in treated plant root extract which was never ever reported in Abelmoschus esculentus. Accordingly in this current research an attempt is made through bioinformatics search tools to predict the target for this ligand 13-Heptadecyn-1-ol and the target was found to be IL-4 receptor. Hence this compound may be used as an anti-inflammatory agent.

Keywords: Red algae, SLF, Epigenetics, GCMS, 13-Heptadecyn-1-ol, IL-4 receptor.