Abstract

FORMULATION AND EVALUATION OF MULTIPARTICULATE DRUG DELIVERY SYSTEM

Rajesh N.*, Swetha A. and Vidya J.S.

Abstract

The present work deals with the process of formulation and evaluation of pellets loaded with aceclofenac sodium (ACS) as model drug though pellitization technique by using the blend of Sodium alginate (SA) and glyceryl palmito stearate (GPS) as hydrophilic and hydrophobic carriers, along with microcrystalline cellulose (MCC) as spheronizer enhancer in various concentrations and examines the influences of various process parameters of drug containing pellets. This system was able to prolong the drug release, minimizing the drug related adverse effects and improve bioavailability in different GI-tract conditions. Formulated drug loaded pellets were investigated for physicochemical properties and drug release potential. Scanning electron microscopy (SEM) studies and calculated sphericity factor confirms the prepared formulations were spherical in nature. The drug loaded pellets were stable and compatable, as confirmed by DSC and FTIR studies. The release of drug was controlled upto 24 h. Intestinal drug release from optimized formulation pellets was compared with the releases behavior of commercially available formulation Aceton SR– 100 mg tablet.

Keywords: Aceclofenac sodium, Pellitization, Bioavailability, Aceton SR?.