Abstract

ANTIULCER EVALUATION OF MUSSAENDA GLABRATA LEAVES ON EXPERIMENTALLY INDUCED ULCER MODELS OF RAT

Abarnadevika A*, Aswathi P.K and Dr. Manisenthil Kumar K.T

Abstract

anti-ulcerogenic potential and antioxidant activity of ethanolic leafextract of Mussaenda glabrata was investigated. The potential of theethanolic extract to serve as antioxidants were assayed by DPPH andABTS radical scavenging activity. Antiulcer activity was determinedby three different models in experimental Wistar rats: Ethanol inducedulcer, Indomethacin induced ulcer and Pylorus ligation model. Oraladministration of ethanolic extract of Mussaenda glabrata at 200 and400mg/kg significantly reduced the gastric lesions with dose dependentulcer inhibition in all the three models. The LPO, MPO and antioxidantlevels (SOD, CAT, and GSH) were significantly restored in treatedgroups compared to ulcer control, proving antioxidant activity of the extract.Histopathological sections showed significant decrease in mucosal ulceration, inflammatorymucosal changes and submucosal edema compared to ulcer control group. These findingsindicate that ethanolic leaf extract of Mussaenda glabrata possesses antiulcer, antisecretoryand cytoprotective activity and, hence, can be used in the traditional management of pepticulcer disease.

Keywords: Cytoprotective, gastric ulcer, pylorus ligation, ethanol induced, Quercetin,