Abstract

IN-VIVO ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF LEAVES PART OF PYRUS PASHIA

Neha Pandey, Dr. Anita Singh* and Janmejay Pant

Abstract

Customary drug experts utilize Pyrus pashia (PP) leaves extract for symptomatic alleviation in Cardiovascular, Respiratory and Gastrointestinal disease and furthermore utilized as antineoplastic agent, antimicrobial, cytotoxicity. Previous studies show the antiinflammatory effect (AIE) of fruit of the Pyrus pashia extract. The present examination was aimed to explore the anti-inflammatory effect of leaves of Pyrus pashia. The leaf extract was extracted by Soxhlet with 70% methanol at room temperature, separated and the filtrate vanished to dryness. The methanolic extract of Pyrus pashia leaves (MEPPL) was suspended in aqueous and utilized per orally in rodents. MEPPL showed valuable effect in acute anti inflammatory property at 150 mg/kg, 100 mg/kg and 50 mg/kg doses. When compared to the standard drug Indomethacin 10 mg/kg the acute effect of the extract was comparable. These observations established the potential acute AIE of Pyrus pashia leaves.

Keywords: Pyrus pashia, anti-inflammatory, Carrageenan.