Abstract

EFFECT OF “KARPURAVALLI” ON ANTIBIOTIC INDUCED HEPATOTOXICITY

Radhika J.*, Jothi G., Brindha G. and Yuvarani S.

Abstract

Liver is the vital organ in our body, which is involved in metabolism and independently involved in many biochemical functions. Liver disease has become one of the major cause of mortality and morbidity all over the world. It is a fifth most common cause of death. Drug induced hepatotoxicity manifests in many ways, from asymptomatic elevation of liver enzymes to complete hepatic failure. Pashanabhedi is an Ayurvedic drug botanically equated as Coleus aromaticus Benth. and traditionally used for treating liver disease. The present study was designed to evaluate the hepatoprotective effect of the aqueous extract of Coleus aromaticus Benth. on rifampicin (54mg/kg bw) induced hepatotoxicity. Wistar strain of rats were divided in to 6 groups with 6 rats each, group - 1 served as normal control, group - 2 served as disease control, group - 3, 4 & 5 were induced with rifampicin and treated with aqueous extract of Coleus aromaticus Benth. 100, 200, 300mg/kg bw orally for 21 days, group – 6 was induced with rifampicin and treated with std drug silymarin (20mg/kg BW for 21 days orally). After intoxicating with Rifampicin the following parameters were analysed - serum Aspartate transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Gamma glutamyl transferase (GGT), Bilirubin, liver glycogen, antioxidant status. Disease control rats showed increased levels of AST, ALT, ALP, Bilirubin, LPO and the levels of serum and tissue protein, GSH, SOD, GPx, Glycogen were significantly decreased compared to normal control rats. The administration of different doses of aqueous extract of Coleus aromaticus Benth lead to the restoration of altered enzymatic and biochemical parameters.The results of the present study clearly depicted the hepatoprotective potentials of aqueous extract of Coleus aromaticus Benth.

Keywords: Hepatic failure, Coleus aromaticus Benth, Rifampicin, Silymarin, Hepatoprotective.