Abstract

FORMULATION AND EVALUATION OF TOPICAL EMULGEL OF KETOCONAZOLE BY CUBOSOMAL TECHNIQUE

Jyoti K. Bachhav*, Bhushan A. Bhairav and Ravindra B. Saudagar

Abstract

This novel particle are prepared by either hydrophilic, lipophilic or amphiphilic molecule prepared by high speed homogenization technique. It is time consuming technique. The aim of this study is to enhance ketoconazole solubility and drug delivery of ketoconazole in biological membrane by preparing ketoconazole emulgel formulation. Emulgel were prepared by using Glycerin monooleate and poloxomer- 407. The prepaid formulations were characterized by Nano size analyzer, poly dispersity, entrapment efficiency, zeta potential, in-vitro drug release. In design formulation optimize batch is selected on the basis of particle size and entrapment efficiency. The experimental result demonstrates that successful development of cubosomal nanoparticle containing ketoconazole for fungal infection targeting formulation.

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