Abstract

HEPATOPROTECTIVE EFFECTS OF OLEUROPEIN, THYMOQUINONE AND FRUIT OF PHOENIX DACTYLIFERA ON CCL4 INDUCED HEPATOTOXICITY IN RATS

Sibghatullah Sangi*, Said Ahmed El-feky , Soad Shaker Ali , Elsamoual IbrahimAhmedani  and Murad Husni Tashtoush

Abstract

Chronic liver diseases commonly result in liver fibrosis and eventually liver cirrhosis. It has been demonstrated that oxygen-derived free radicals and lipid peroxidation play a critical role in the pathogenesis of various liver diseases including hepatic fibrosis. Our research aim was the evaluation of the Active ingredients of Olive, Nigella Sativa, and fruit of Phoenix dactylifera as hepatoprotective against hepatocellular damage induced by hepatotoxins. In this study the effect of Thymoquinone , Oleuropein and fruit of Phoenix dactylifera were investigated in rats affected by hepatotoxicity and cirrhosis as a result of administration of a chemical substance (CCl4). Rats were divided into five groups 10 rats in each. The level of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and alkaline phosphatase (ALP) was determined, regarding its relation to liver damage. Liver tissues were investigated to compare between healthy and infected ones. It was found that Thymoquinone ,Oleuropein and Phoenix dactylifera fruit significantly revised the changes produced by CCl4 on hepatic cells and enzymes.

Keywords: Oleuropein , Nigella sativa, Phoenix dactylifera, Hepatotoxicity