Abstract

THE STUDY OF ANTI-INFLAMMATORY RESPONSE IN RELATION WITH ANTITRYPTIC ACTIVITY OF 4-HYDROXY-4-PHENYL PIPERIDINE DERIVATIVES

*Dr. Kiran Rafiq , Dr. Zafar Saied Saify, Seema Ashraf, Ghufran Saeed 

Abstract

Piperidine ring containing compounds are more potent and diverse pharmacological moieties and focal chemical entity. There are various piperidine ring containing compounds, which exhibit strong antiinflammatory activity furthermore these compounds were found to have strongly compatible with trypsin enzyme that has been proved as a an excellent tool for controlling the inflammation. Depending on these facts , the present study was done to examine the interaction of 4-Hydroxy-4-phenyl piperidine synthesized derivatives with trypsin enzyme through agar plate method. The outcome of study helped to evaluate the compounds in two ways as the compounds were found in strong interaction with this digestive enzyme that behavior will help to work against inflammation.

Keywords: Inflammation, trypsin, piperidine