Abstract

INVESTIGATION INTO THE ANTI-ULCER ACTIVITY OF THE METHANOL EXTRACT OF STEMONOCOLEUS MICRANTHUS HARMS, BARK (FAM: LEGUMINOSEAE)

Ezea, C.C*; C.T. Nnamdi-Okenwa, C.O. Ezugwu, F.C. Anowi,S.C. Ezea.

Abstract

The objective of this study was to investigate the anti-ulcer activity of methanolic extract of Stemonocoleus micranthus Harms, Bark (Leguminoseae) in rats. Fresh dried barks of Stemonocoleus micranthus were extracted by cold maceration technique with methanol as the solvent and the yield was concentrated on a rotary evaporator. Anti-ulcer effects of the methanolic extract at 25, 50 and 100 mg/kg were evaluated in rats using indomethancin induced ulcer model. Phytochemical analysis and lethality tests (LD50) were carried out using standard methods. Results showed that the methanolic extract exhibited significant (P

Keywords: Anti-ulcer activity, S. micranthus stem bark, phytochemical analysis.