Abstract

PROTECTIVE AND CURATIVE ACTIVITY OF ETHANOL LEAF EXTRACT OF CORCHORUS OLITORIUS IN THIOACETAMIDE EXPOSED RATS

Dr. Sule O. J.*, Arhoghro E. M. and Erigbali P.

Abstract

The present study was undertaken to evaluate the protective and curative effect of ethanol leaf extract of Corchorus olitorius against thioacetamide-induced toxicity in experimental rats. The animals were exposed to thioacetamide at a dose of 400 mg/kg body weight i. p for 3 selected days exhibited a significant increase (p < 0.05) in hepatic and renal biomarker enzymes namely; ALT, AST, ALP and increase concentration of bilirubin, urea and creatinine. Pre-treatment and posttreatment with extract of Corchorus olitorius at dose of 200 mg/kg body weight orally significantly decrease the hepatic and renal marker enzymes and concentration of bilirubin, urea and creatinine. The effects of Corchorus olitorius leaf extract on histological features of liver of experimental rats indicated that the normal control, extract pretreated and post-treated showed normal hepatic architecture while positive control group B shows occluded central vein and dilated sinusoids. Histopathological section of the kidney showed normal kidney stroma with Bowman’s capsule with glomerulus (renal corpuscle) and renal tubules, in pretreated, post-treated and normal control groups, while thioacetamide treated group showed infiltration of inflammatory cells. Present investigation showed that the ethanol leaf extract of Corchorus olitorius have considerable protective and curative effect against thioacetamide-induced hepatic and renal oxidative damages in rats.

Keywords: Corchorus olitorius, nephroprotective, hepatoprotective, thioacetamide, creatinine.