Abstract

EFFECT OF METHIDATHION ON SOME BLOOD PARAMETERS AND LIVER ENZYMES IN LABORATORY MICE MUS MUSCULUS L

Sami J. Al-Maliki and Eman H. Rahi*

Abstract

The present study aimed to investigate the effect of methidathion on blood parameters and liver enzymes in mice when injected by two doses. Adult male and female mice divided into three groups for each sex (8 for each group), the first group injected intraperitoneal (i.p.) with normal saline as a control group, the second and third groups were injected (i.p.) with (1.2, 2.4 mg/kg of body weight) methidathion respectively for 15 day. The results showed significant decrease in red blood cell count (RBC), packed cell volume (PCV), hemoglobin (Hb) in both doses in male mice.in female, The results showed significant decrease in packed cell volume (PCV) in low dose, significant decrease hemoglobin (Hb) in both doses compared control group, there was also showed significant increase in the total number of white blood cells(WBCS) in both dose compared control group. the study showed a significant increase in the liver enzyme alanine transaminase (ALT), alkaline phosphatase (ALP) in male and female treatment methidathion compared control group.

Keywords: Methidathion, Blood Parameter, Liver Enzyme, Mice.