Abstract

ANALGESIC, ANTI-PYRETIC AND ANTI-INFLAMMATORY ACTIVITY OF THE LYMPH EXTRACTED FROM BELLAMYA BENGALENSIS F. ANNANDALEI IN RODENT MODELS

Moumita Ray, Nilanjana Deb, Rana Datta and Shila Elizabeth Besra*

Abstract

Innumerable scientific reports have identified the therapeutic roles of animal toxin and secretions. Animal secretions exhibit physiological responses like hemolysis, platelet aggregation, and modulation of membrane bound enzymes etc. Bellamya bengalensis, a freshwater edible snail, has been used as medicine since ancient time for the cure of ailments like asthma, conjunctivitis etc. The present study aims to evaluate the anti-inflammatory, analgesic and antipyretic activity of the secretion of Bellamya bengalensis f. annandalei designated as LBB in rodent models. Acute toxicity, acute anti-inflammatory study with carrageenan induced rat paw oedema, croton oil induced ear inflammation in mice, subacute study with cotton-pellet induced granuloma and chronic study with Freund‟s adjuvant induced polyarthritis. Mechanism of action, using arachidonic acid induced rat pawoedema. Analgesic studies include writhing, hot plate, tail clip method. Anti-pyretic activity with Brewer‟s yeast induced pyrexia in rat. Pretreatment with LBB inhibits arachidonic acidinduced paw inflammation by both the COX-LOX pathway of arachidonic acid metabolism. This study emphasizes on the exploration of selective and less toxic lead therapeutic with better therapeutic indices.

Keywords: Bellamya bengalensis, Secretion, Inflammation, Pain, Pyrexia.