Abstract

DESIGN AND DEVELOPMENT OF SINGLE CORE OSMOTIC PUMP (SCOP) FOR POORLY SOLUBLE DRUG

Nityanand Zadbuke*, Sadhana Shahi, Rajendra Marathe, Rajesh Nawale and Satish Rojekar

Abstract

The present work aims towards the design and development ofcontrolled release formulation of poorly soluble drug Carbamazepine(CBZ) based on osmotic technology by using single core osmoticpump (SCOP) approach. Carbamazepine (CBZ) is a first-lineantiepileptic drug (AED) drug used for the treatment of partial andtonic-clonic seizures. The concentrations of Natrosol 250L (ratecontrolling polymer) and Sodium chloride (Osmogen) added to thecore tablet were optimized. Cellulose acetate (CA) and Polyethyleneglycol (PEG 8000) were used as semipermeable membrane and poreformer, respectively. The effect of different formulation variablesnamely concentration of rate controlling polymer and osmogen in thecore tablet, % pore former, % weight gain, orifice diameter, pH of the dissolution mediumand agitation intensity on the in vitro release was studied. CBZ release was directlyproportional to % of Osmogen and inversely proportional to % of rate controlling polymer incore tablet. The system was found to deliver CBZ at a zero order rate for 24 h independent ofpH and agitation intensity can be useful as improved AEDs efficacy, tolerability and patientcompliance.

Keywords: SCOP, Natrosol 250L, Cellulose acetate, Osmogen, PEG 8000.