Abstract

ANTIHYPERGLYCEMIC AND HEAMATOLOGICAL EFFECT OF COMBINATION OF BOUGAINVILLEA SPECTABILIS AND CATHARANTHUS ROSEUS LEAVES ON ALLOXAN-INDUCED DIABETIC WISTAR RATS

Firdous Majeed*, Hakim Mudasir Maqsood and Kusum Singh

Abstract

Bougainvillea spectabilis and Catharanthus roseus leaves are known to have medicinal properties. Antihyperglycemic property and other beneficial effects of their plant extract were evaluated in Alloxaninduced diabetic Wistar rats. A total of 24 mature rats weighing 200±10g were used for this study. They were divided into four groups of 6 rats each. Group I was conserved as normal control. Group II, III and IV were made diabetic by intraperitoneal injection of Alloxan. After being confirmed as diabetic, Group II was conserved as diabetic control, Group III was administrated plant extract (Bougainvillea spectabilis and Catharanthus roseus) at 300 mgkg-1 body weight and Group IV was administrated standard drug, Glibenclamide at 5 mgkg-1 body weight for defined time intervals. The blood glucose level and heamatological parameters viz. red blood and white blood cells and some of their functional indices were evaluated in diabetic treated groups on 7th, 14th and 21th day after daily oral administration of plant extracts and were compared with the respective controls. The result of study revealed that the plant extract at 300 mgkg-1 body weight exhibited significantly hypoglycemic activity at defined interval and had beneficial effect on all studied heamatological parameters viz. RBC, WBC, Hb, PVC, SGOT and SGPT.

Keywords: Bougainvillea Spectabilis, Catharanthus Roseus, Diabetes, Heamatology, Wistar Rat.