Abstract

CREUTZFELDT-JAKOB DISEASE ---A BRAIN WASTING DISEASE (CJD-A BRAIN WASTING DISEASE)

B. Revathi*, J. Divya latha, M.Malleswari, N. Sreekanth

Abstract

This review provides the rationale and background for the development of diagnostic criteria for Creutzfeldt-Jakob Disease(CJD), which is recent outbreak including risk factors and neuropathological findings in human, epidemiology, and clinical characteristics, along with treatment, and future research directions. Overall, there is substantial research to suggest that the dementia that may co-occur with this CJD different from dementia of other neurodegenerative disorders. Future prospectives for further research necessities to better define core symptoms, mode of transmission, efficacy of treatment in human are highlighted.

Keywords: neurodegenrative disorder, abnormal prion protein, methionine/valine polymorphism, rapidly progressive dementia, bovine spongiform encephalopathy, magnetic resonance imaging.