Abstract

COMPARATIVE EFFECTS OF CANAGLIFLOZIN AND METFORMIN ON CARDIAC DYSFUNCTION AND TESTICULAR DAMAGE IN DIABETIC RATS

Bosy A. Abd El-Motelp* and Hend A. Sabry

Abstract

Purpose: The current study was carried out to investigate the antidiabetic effect of canagliflozin and metformin on induced cardiac dysfunction and testicular damage in diabetic rats. Methods: Male albino rats were classified into 4 groups. Control group received distilled water(C). Diabetes was induced in second, third and fourth groups rats by feeding them with a high-fat diet(HFD) for 3 weeks followed by intraperitoneal injection of a low dose of streptozotocin (35 mg/kg) and continued with butter supplementation in line with SD for another one week. Second group remained as the untreated diabetic group(D). The third group received orally (10 mg/kg) daily dose of canagliflozin (D + CAN) for 4 weeks. The forth group received orally (100 mg/kg) daily of Metformin (D + MET) for 4 weeks. Results: CAN and MET treatment significantly (P

Keywords: Diabetes, Canagliflozin, Metformin, Heart, Testis, Rats.