Abstract

A REVIEW ON THE THERAPEUTIC POTENTIAL OF QUINOXALINE DERIVATIVES

Ali Irfan*, Ifrah Sabeeh, Muhammad Umer, Andleeb Zahra Naqvi, Hira Fatima, Sadia Yousaf and Zuriat Fatima

Abstract

Quinoxaline nucleus based derivatives have attracted researcher’s attention due to privileged and extensive applications in medicine, pharmaceuticals and pharmacological fields. Quinoxaline moiety is a part of various antibiotics such as echinomycine, levomycine, actinoleutine and also act as antiviral, anti-diabetic, anti-inflammatory, kinase inhibitors, anticancer, ion channel regulators and anti-protozoa agent. Various synthetic methodologies and strategies are developed to prepare quinoxaline compound libraries due to pivotal focal point of research activity in the field of pharmacology and medicine. In this review the substituted quinoxaline scaffolds synthetic chemistry, biological activities and applications are summarized.

Keywords: Quinoxaline, pharmaceutical, antimicrobial, anticancer, anti-inflammatory, anti-diabetic.