Abstract

BIOINFORMATICS ANALYSIS ON SQUALENE EPOXIDASE 2 IN PANAX NOTOGINSENG

Li Gun*, Lu Jingqi and Tian Han

Abstract

Panax notoginseng is a commonly used medicinal herb. In this paper, from the perspective of bioinformatics, the main physical characteristics of Squalene Epoxidase 2 in Panax notoginseng are studied. The isoelectric point, theoretical pI and hydrophobicity etc, of the polypeptide are studied and the results show that the theoretical isoelectric point of Squalene Epoxidase 2 in Panax notoginseng is 9.13, its molecular weight is 60263.16, its instability index is 29.87, there are three transmembrane regions in the Squalene Epoxidase 2 sequence, last, the secondary structure of Squalene Epoxidase 2 shows that there are many secondary structure kinds, rate of alpha helix are 173(31.74%), rate of beta sheet are 133(24.40%), rate of beta turn are 69(12.66%) and rate of coil are 170(31.19%) respectively. Finally, this paper also discussed the three-dimensional structure and phosphorylation site of Squalene Epoxidase 2 in Panax notoginseng.

Keywords: Squalene Epoxidase 2; Panax notoginseng, Bioinformatics analysis; traditional Chinese medicine.