Abstract

SUBSTITUTED BENZIMIDAZOLE A POTENTIAL DRUG CANDIDATE: AN OVERVIEW

Avinash P. Tupe*, Ganesh V. Devkate, Sandeep S. Tate, Sonali B. Deokate, Atul S. Bhujbal and Dr. Rajendra N. Patil

Abstract

Benzimidazole has diverse biological potential and the easy synthetic routes for synthesis have taken attention of the chemists, pharmacologists and researchers. The review of synthetic methods of substituted benzimidazoles and this new class of substituted benzimidazole has shown a wide spectrum of biological activities. The biological profile of these new generations of benzimidazoles presents much progress with regards to the old compounds. The antiinflammatory, analgesic, antibacterial, antifungal activities are the most reported activities on benzimidazole compounds. The currently used analgesic and anti-inflammatory drugs have limitations for therapeutic use since they cause gastrointestinal and renal side effects that are inseparable from their pharmacological activities. For this purpose, the synthesis of new compounds devoid of such side effects has become an important goal for medicinal chemists.

Keywords: Benzimidazole, wide spectrum, anti-inflammatory, analgesic.