Abstract

ANTI-ADHESION THERAPY: A POTENTIAL ALTERNATE APPROACH TO OVERCOME DRUG RESISTANCE AMONG INFECTIOUS MICROORGANISMS

Gayathri Devaraja*and S Sunil Kumar

Abstract

Pathogenesis of the infectious microorganisms begins with the adhesion and subsequent colonization on the different organ surfaces, made possible due to the presence of protein/polysaccharide at the surfaces of the pathogen which are called adhesins. The emergence of drug resistant bacteria in the recent past encourage searching for novel means to treat most dreadful diseases. The present article reviews the potential alternative approach to treat various infectious diseases and strategies to overcome drug resistance among infectious microorganisms using anti-adhesins such as carbohydrate lectins, cranberry extract, bromelain from fruit or stem of pineapple, receptor analogues, adhesion analogs and other dietary inhibitors.

Keywords: Anti-adhesins, Cranberry, lectins, proanthocyanidins, Anti-L-selectin antibody.