Abstract

THE EFFECT OF DIFFERENT CONCENTRATION OF PECTIN SOLUTION IN CALCIUM PECTINATE BEADS ON THE ENTRAPMENT OF INSULIN

Prabakaran V.* and Dr. N. V. Satheesh Madhav

Abstract

Multiple unit dosage forms for oral delivery of bioactive agents offer many advantages over single unit dosage forms. Insulin, Encapsulated in a calcium pectinate gel beads by dispersing the insulin in a Solution of pectin, and beads are prepared by dropping the dispersion in calcium chloride, the beads Formed by Inotropic gelation. The externally crosslinked beads are suitable for Water in soluble and cationic drugs and it is limited for water soluble and drugs low Molecular weight. The purpose of present study was checking the entrapment efficiency (EE) and drug release With externally crosslinked beads. The EE increased up to 39% to 93% by using CaCo3 as a internal cross linking agent with lower concentration of CaCl2 (1%). The EE decreased with increasing the concentration of CaCl2 (5%) up to 14%. The beads where studied for micromeritic properties, SEM, DSC, Swelling and in-vitro studies in acidic medium. SEM micrographs revealed the Leaching of drug and tightness of gel. The drug release was found to be depending on the solubility of drug with no effect of gel characteristics of pectin.

Keywords: Inotropic Gelling, Calcium Pectinate Beads, Entrapment.