Abstract

PHARMACOGNOSTICAL AND PHYTO-CHEMICAL STANDARDIZATION OF PATHADI CHOORNA- A POLYHERBAL FORMULATION FOR POLYCYSTIC OVARIAN SYNDROME

Archana S.*, L. P. Dei, Harisha C. R. and V. J. Sukla

Abstract

Introduction: Ayurveda has become significantly more popular all over the world because of the effective and curative nature for chronic disease with less toxicity. Most of the Ayurvedic drugs are very effective but lack standardisation. Standardization of drugs means confirmation of its identity and determination of its quality and purity. Pathadi choorna was described by Acharya Susruta in the context of Granthi artavadushti as a kwatha formulation. Polycystic Ovarian Syndrome (PCOS) can be compared with granthi artavadushti due to the grathila (polycystic) appearance of ovaries along with abnormal uterine bleeding in the form of Oligomenorrhoea or a phase of amenorrhoea followed by severe bleeding with clots. The Polycystic Ovarian Syndrome (PCOS) is a syndrome of ovarian dysfunction along with the cardinal features of Hyperandrogenism and polycystic ovarian morphology. Pathadi choorna was selected as the trial drug for polycystic ovarian Syndrome. Aim: To develop the pharmacognostical and phytochemical profile of Pathadi choorna. Material and Methods: Pathadi choorna was prepared as per classical methods and analytical findings were systematically recorded. The samples were subjected to organoleptic analysis, physicochemical analysis and HPTLC examination by optimizing the solvent systems. Results and Conclusions: Pharmacognostical profile of Pathadi choorna was established. The presence of prismatic crystals, spool cells, fibres, stone cells, black debris, were the characteristic features observed in the microscopy of the finished product. Physico-chemical analysis showed Loss on drying 9.24% w/w, ash value 5.54% w/w, and pH-6.5. HPTLC fingerprinting profile of Pathadi choorna revealed 5 spots at 254 nm and 6 spots at 366 nm.

Keywords: Organoleptic, Pharmacognosy, PCOS, Pathadi choorna, Physio-chemical