Abstract

DESIGN AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES CONTAINING KETOPROFEN

Navneet Verma*, Shikha Deshwal

Abstract

Transdermal Drug Delivery System (TDDS) is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin is an effective medium from which absorption of the drug takes place and enters in to circulatory system. The purpose of this research work was to formulate and evaluate of transdermal drug delivery system of Ketoprofen using blend of two polymeric combinations, Polyvinylpyrrolidone K-30 (PVP) and Ethyl cellulose (EC) for improvement of bioavailability of drug and reducing toxic effects. Di butyl phthalate used as plasticizer and DMSO used as permeation enhancer at 40% w/w and 5% v/w concentration of the total polymer weight respectively while chloroform used as a solvent system. The transdermal patches were evaluated for their physiochemical properties like thickness, weight variation, flatness, folding endurance, drug content, swellability, surface pH. In addition interaction between drug & polymer was also evaluated. The patches were found to be free of any skin irritation UV, FTIR and DSC studies showed no interaction between drug and polymer.SEM of the prepared transdermal patches were taken to see the drug distribution pattern. The kinetic models used were zero and first order equations, Higuchi’s and Korsmeyer-Peppas models. In vitro permeation studies were done using Franz diffusion cell through rat abdominal skin and showed zero order release mechanism. The formulation F4, combination of polymer (EC: PVP) showed maximum release of 85.92% in 10 hr. and formulation F1 (Ethyl cellulose alone) showed minimum release 68.32% in 10 hr. All the formulaions showed non fickian type diffusion. The study results revealed that the problems of ketoprofen on oral administration like first pass metabolism and G.I. disturbances can be overcome by applying ketoprofen topically in the form of transdermal patch.

Keywords: Transdermal drug delivery system, Polyvinylpyrrolidone K-30, Korsmeyer- Peppas.