Abstract

DRUG-EXCIPIENT INTERACTION STUDY OF TRAMADOL HCL WITH POLYMERS

Bhakti Mali*, Sumedh N. Moharil, Vaibhav Mhasal and Mahesh B. Narkhede

Abstract

Drug-Excipient interaction study is important for the stability and good quality of product and to avoid the incompatibilities during production. various methods are available for that study like D,S.C, I.R. etc. Differential Scanning Calorimetry is widely used to observe or predict any physico-chemical interaction between drug and excipient Infrared absorption spectroscopy is related to the absorption of infrared radiation and get excited to excited state from the red end of visible spectrum to microwave region. That study totally depends on chemical and structural changes and thermal activity of compounds.

Keywords: D.S.C., I.R., Interaction study.